![]() Whether such radical tumor resection exerts an influence on overall survival time was controversially discussed for a long time with some studies indicating no influence and others showing a positive correlation 9, 10, 11, 12, 13, 14. Maximizing cytoreduction by tumor resection through novel neurosurgical techniques still represents the first line therapy for glioma patients, with current trends focusing on the development of increasingly tailored treatment options with integration of molecular strategies in an attempt to at least maximize patient survival time and improve quality of life 6, 7, 8.Ī complete tumor resection has usually been understood to imply removal of the pre-operatively defined contrast-enhancing tumor portions. Although a cure remains elusive despite implementation of all currently available treatment options including radical surgical resection of the tumor mass followed by adjuvant radio-chemotherapy, this strategy serves to secure a histological diagnosis and improves response rates for radio-chemotherapy 4, 5. Amongst them, glioblastoma (GBM, WHO°IV) carries the worst prognosis with patients succumbing after a median survival time of 14 months 3. Gliomas are primary CNS tumors accounting for almost 80% of all diagnosed tumors of the brain originating from brain parenchyma, with malignant gliomas constituting the most common brain tumors in adults 1, 2. The FGA/B grading method provides high prognostic value with respect to overall survival time in relation to the extent of location-dependent tumor resection. We offer the opportunity to classify brain tumors in a dependable and reproducible manner. Investigation of outcome revealed that FGA were characterized by a significantly longer overall survival time compared to FGB. We performed a clinical investigation comprising 322 patients with gliomas and developed a novel classification system of preoperative tumor status, which considers tumor operability based on two graduations (Friedlein Grading - FG): FGA with lesions at safe distance to eloquent regions which can be completely resected and FGB referring to tumors which can only be partially resected or biopsied. Despite existing assessment methods, the availability of a simple but reliable preoperative grading based on functional data would therefore prove to be indispensable for the prediction of postoperative outcome and hence for overall survival in glioma patients. ![]() ![]() Consideration of tumor localization in relation to functionally eloquent brain areas has been gaining increasing importance. Surgical treatment is accepted to be the first line of therapy, with recent studies revealing that maximal possible tumor reduction exerts significant impact on patient outcome. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.Despite advances in multimodal treatments, malignant gliomas remain characterized by a short survival time. The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved.
0 Comments
Leave a Reply. |